Evidence map›Paper›PMID 41321954›Full record

ArticlePeerJ2025

Bioinformatics-based identification of RAS disequilibrium involved in post-hemorrhagic shock mesenteric lymph return-mediated acute kidney injury in mice.

Yujie Jin, Jing Wang, Shaoxuan Wang, Yuting Li, Kun Su, Niuniu Feng, Huibo Du, Limin Zhang, Xiuhong Yang, Chun-Yu Niu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yujie Jin *Institute of Microcirculation, Hebei North University, Zhangjiakou, China.
Jing Wang *Institute of Microcirculation, Hebei North University, Zhangjiakou, China.
Shaoxuan WangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Yuting LiInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Kun SuInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Niuniu FengInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Huibo DuInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Limin ZhangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Xiuhong YangSchool of Basic Medical Science, North China University of Science and Technology, Tangshan, China.
Chun-Yu NiuInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Zi-Gang ZhaoInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.

Funding

Natural Science Foundation of Hebei Province
6 · The paper itself

Abstract

Post-hemorrhagic shock mesenteric lymph (PHSML) return plays a critical role in the development of acute kidney injury (AKI). However, the molecular mechanism underlying PHSML-mediated AKI remains unclear. In this study, bioinformatics analysis identified key common targets of hemorrhagic shock and AKI, revealing significant enrichment in the renin-angiotensin system (RAS). To further investigate the role of RAS in PHSML-mediated AKI, we established mesenteric lymph duct ligation (MLDL) technology in mice and confirmed that MLDL alleviated hemorrhagic shock-induced AKI. Subsequently, male C57BL/6 mice subjected to hemorrhagic shock were treated with the angiotensin converting enzyme (ACE) inhibitor enalapril, angiotensin (1-7) (Ang (1-7)), and angiotensin II (Ang II) type 1 receptor (AT1R) inhibitor losartan. Additionally, mice with hemorrhage and MLDL were treated with Ang II, the Mas receptor (MasR) inhibitor A-779, or subjected to

Indexed as

Acute Kidney InjuryComputational BiologyLymphRenin-Angiotensin SystemShock, HemorrhagicAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAngiotensin IAngiotensin IIAnimalsDisease Models, AnimalEnalaprilLosartanMaleMiceMice, Inbred C57BLAce2 protein, mouseAngiotensin-Converting Enzyme 2Angiotensin-Converting Enzyme InhibitorsAngiotensin Iangiotensin I (1-7)Angiotensin IIEnalaprilLosartanPeptide FragmentsPeptidyl-Dipeptidase AReceptor, Angiotensin, Type 1Acute kidney injuryAngiotensin converting enzymeHemorrhagic shockMesenteric lymphRenin-angiotensin system

Identifiers

PMID41321954
PMCPMC12659705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.