ReviewInternational journal of nanomedicine2025
Key Role of STAT3 in Osteoarthritis: From Pathogenic Mechanisms to Targeted Therapy.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Follicular Immune Checkpoint: PD-1/PD-L1 and Immune Tolerance in Oocyte Competence and IVF Failure.International journal of molecular sciences · 2026Review
- Endoplasmic Reticulum Stress as a Stage-Dependent Regulatory Hub in Rheumatoid Arthritis.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is a multifactorial degenerative disease characterized by articular cartilage degeneration. Currently, the underlying mechanisms of its pathogenesis remain unclear, and effective treatment options are limited. Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor involved in various physiological and pathological processes, and recent evidence suggests its association with the pathogenesis of OA. Janus kinase (JAK)/interleukin-6/STAT3 signaling pathway plays an important role in STAT3 involved in disease occurrence. This review summarizes the common signaling pathways involving STAT3 in OA and its roles in different cell types. Additionally, we systematically discuss the latest therapeutic approaches targeting STAT3 for OA treatment, aiming to identify drugs that can enhance delivery efficiency and binding affinity. By discussing molecular mechanisms and treatment methods, this review provides a foundation for subsequent research on the STAT3 signaling pathway and OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.