Evidence map›Paper›PMID 41321835›Full record

ArticleFrontiers in microbiology2025

The dltC gene contributes to polyhexamethylene biguanide resistance in

Chenyang Guo, Congcong Wang, Qihui Chen, Sophia Hao Zheng, Fengji Zhang, Jiayu Yan, Haoyang Brady Long, Jing Luo, Xiaoyan Xuan, Peng Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chenyang GuoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Congcong WangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Qihui ChenDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Sophia Hao ZhengKeystone Academy, Beijing, China.
Fengji ZhangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Jiayu YanDepartment of Animal Biology, College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
Haoyang Brady LongNanjing Foreign Language School, Nanjing, China.
Jing LuoDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xiaoyan XuanDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Peng WangDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Huaixin ZhengDepartment of Microbiology and Immunology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies. Polyhexamethylene biguanide (PHMB), a cationic polymer with broad-spectrum antimicrobial activity and low toxicity, has been extensively used in medical and personal care applications. Although no definitive cases of bacterial resistance to PHMB have been reported, resistance to other cationic agents suggests the potential resistance to PHMB. In this study,

Indexed as

bacterial resistancedlt operonhydrophobicityPHMBStaphylococcus aureus

Identifiers

PMID41321835
PMCPMC12662226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.