ArticleKidney diseases (Basel, Switzerland)
Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Glomerular Diseases.Biomedicines · 2026Article
- Moving Mendelian Randomization From Traditional Risk Factors to Molecular Targets for Drug Development and Clinical Trials in Nephrology.Kidney international reports · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Introduction: Endothelium-mediated regulation of vascular tone plays a crucial role in modulating vascular functions, especially in the kidney, a highly vascularized organ. Therapeutic interventions targeting this process, such as endothelin axis blockage, have demonstrated positive results across various kidney diseases. However, the long-term effects remain poorly explored. Mendelian randomization (MR) and Transcriptome-Wide Association Study (TWAS) provide an approach to investigate the lifelong effects of genetically determined variations in endothelial vasoactive pathways on renal outcomes, mimicking a naturally occurring randomized controlled trial. Method: The primary outcome is the estimated glomerular filtration rate (eGFR), and secondary outcomes include urine albumin-to-creatinine ratio (UACR), rapid kidney function decline, chronic kidney disease (CKD), and various cardiovascular events. From published Genome-Wide Association Studies (GWASs), we extracted summary statistics, employed the inverse variance weighted method for the main MR analysis, complemented by various sensitivity analyses, and utilized the S-PrediXcan for Transcriptome-Wide Association Study (TWAS) analysis. Result: Genetically predicted eNOS pathway activation correlated with higher eGFR (0.03, 95% CI: 0.01-0.05, Conclusion: Our results shed light on a significant effect of endothelial vasoactive pathways in kidney-related outcomes, which hold promise for alternative targeted therapies in CKDs.
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