ReviewBioMed research international2025
Opposing Immune Cell Responses to Viral Infections in Kidney Transplant Recipients: A Bibliometric Analysis.
Review in BioMed research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Opposing Immune Cell Responses to Viral Infections in Kidney Transplant Recipients: A Bibliometric Analysis.BioMed research international · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infections remain a significant concern in kidney transplant recipients, affecting both graft and patient survival. Understanding the immune cell responses to various pathogens is essential for developing effective prevention and treatment strategies. Objective: The objective was to analyze research trends in kidney transplantation infection literature and characterize differential immune cell responses to common posttransplant infections. Methods: A comprehensive analysis of 4277 English language articles on kidney transplantation and infection from the Web of Science Core Collection was conducted. Research output, international collaboration, and keyword trends were analyzed. Immune cell responses to various infections in kidney transplant recipients were systematically evaluated. Results: The United States (3845 articles), France (1819 articles), and China (1342 articles) were the leading contributors to research in this field. Key research clusters included immunosuppression management, viral infections, and treatment strategies. Most significantly, analysis of immune cell populations revealed distinct patterns of response to different infections. Cytomegalovirus infection increased CD3 + CD8 + midCD56+ NK-T cells and CD3 + CD8+ T cells, while BK polyomavirus reactivation decreased CD4+ and CD8+ T cells. Under immunosuppressive conditions, NK cell numbers were reduced. Kidney transplant infections directly caused decreases in CD4 + CD25+/CD4+ T cells, CD8 + CD25+/CD8+ T cells, and HLA-DR+ monocytes, reflecting differential immune modulation based on infection type. Conclusion: Different pathogens elicit distinct immune cell responses in kidney transplant recipients, with some infections enhancing specific immune cell populations while others suppress them. These differential patterns of immune modulation reflect the complex interplay between immunosuppressive therapy and infectious agents. Understanding these specific immune responses provides valuable insights for developing targeted infection management strategies and improving monitoring protocols in transplant recipients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.