Evidence map›Paper›PMID 41321665›Full record

ArticleAJOG global reports2025

pHyph, a novel antibiotic-free treatment for bacterial vaginosis, promotes Lactobacillus growth and reduces the abundance of pathogens in the vagina.

Emilia Lahtinen, Luisa W Hugerth, Gabriella Edfeldt, Annette Säfholm, Sten Kornfält, Lars Engstrand, Helena Strevens, Ina Schuppe-Koistinen

Abstract read
In one paragraph

Article in AJOG global reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emilia LahtinenCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden (Lahtinen, Edfeldt, Engstrand and Schuppe-Koistinen).
Luisa W HugerthDepartment of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden (Hugerth).
Gabriella EdfeldtCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden (Lahtinen, Edfeldt, Engstrand and Schuppe-Koistinen).
Annette SäfholmGedea Biotech AB, Medicon Village, Lund, Sweden (Lahtinen, Säfholm, Kornfält and Strevens).
Sten KornfältGedea Biotech AB, Medicon Village, Lund, Sweden (Lahtinen, Säfholm, Kornfält and Strevens).
Lars EngstrandCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden (Lahtinen, Edfeldt, Engstrand and Schuppe-Koistinen).
Helena StrevensGedea Biotech AB, Medicon Village, Lund, Sweden (Lahtinen, Säfholm, Kornfält and Strevens).
Ina Schuppe-KoistinenCentre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden (Lahtinen, Edfeldt, Engstrand and Schuppe-Koistinen).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age worldwide, caused by dysbiosis of the vaginal microbiome. Despite its prevalence, the underlying molecular mechanisms remain poorly understood, making diagnosis and treatment challenging. Although antibiotics are the standard therapy, recurrence rates are high, up to 50% within 1 year, and repeated treatments contribute to the rise of antimicrobial resistance. There is an urgent need for alternative, sustainable, and microbiome-friendly treatment options. Objective: To evaluate whether Study design: In a randomized, double-blind, placebo-controlled trial, vaginal swabs were collected from 152 women diagnosed with BV. Microbiome composition was assessed before and after a 6-day treatment with Results: Conclusions:

Indexed as

antibiotic-free treatmentbacterial vaginosisdysbiosislactobacilliqPCRvaginal microbiome

Identifiers

PMID41321665
PMCPMC12663627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.