Evidence map›Paper›PMID 41321657›Full record

ArticleJAC-antimicrobial resistance2025

Bacteriophage pharmacodynamics studied in an

M L G Attwood, Pippa Griffin, Patryk Smorowinski, Alan Noel, Melissa Haines, Andrew Millard, Karen Adler, Martha Clokie, Alasdair Peter Macgowan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M L G AttwoodBristol Centre for Antimicrobial Research & Evaluation (BCARE), Severn Infection Sciences, Pathology Sciences Building, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.ORCID https://orcid.org/0000-0003-1047-2098
Pippa GriffinBristol Centre for Antimicrobial Research & Evaluation (BCARE), Severn Infection Sciences, Pathology Sciences Building, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
Patryk SmorowinskiBristol Centre for Antimicrobial Research & Evaluation (BCARE), Severn Infection Sciences, Pathology Sciences Building, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
Alan NoelBristol Centre for Antimicrobial Research & Evaluation (BCARE), Severn Infection Sciences, Pathology Sciences Building, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.
Melissa HainesBecky Mayer Centre for Phage Research, Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Andrew MillardBecky Mayer Centre for Phage Research, Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Karen AdlerBecky Mayer Centre for Phage Research, Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Martha ClokieBecky Mayer Centre for Phage Research, Department of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Alasdair Peter MacgowanBristol Centre for Antimicrobial Research & Evaluation (BCARE), Severn Infection Sciences, Pathology Sciences Building, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bacteriophage therapy offers an alternative way to counter the menace of increasing antimicrobial resistance. Despite its use in clinical practice for many decades the basic tools to study the translational pharmacodynamics of phages are not available and it is recognized that lack of understanding of phage pharmacokinetics/pharmacodynamics (PK/PD) is a severe limitation in individual patient use and clinical trial design. Methods: Traditional Results: In TKCs, the four Conclusions: An

Identifiers

PMID41321657
PMCPMC12662236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.