Evidence map›Paper›PMID 41321636›Full record

ArticleiScience2025

Medial prefrontal cortex activity precedes dorsomedial striatum in need for change during history-based flexible behavior.

Áron Kőszeghy, Wei Xu, Mingshan Liu, Peiheng Lu, Long Wan, Tong Deng, Sungmin Kang, Peggy Seriès, Jian Gan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Áron KőszeghyUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.
Wei XuUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.
Mingshan LiuUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.
Peiheng LuInstitute of Adaptive Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh EH8 9AB, UK.
Long WanUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.
Tong DengInstitute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh EH16 4SB, UK.
Sungmin KangUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.
Peggy SerièsInstitute of Adaptive Neural Computation, School of Informatics, The University of Edinburgh, Edinburgh EH8 9AB, UK.
Jian GanUK Dementia Research Institute at the University of Edinburgh, Edinburgh EH16 4SB, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being cognitively flexible is vital for survival, and its impairment is central to many psychiatric and neurodegenerative disorders. Both the medial prefrontal cortex (mPFC) and dorsomedial striatum (DMS) are essential for cognitive flexibility, but their specific roles-particularly which region first detects and encodes environmental changes-remain debated. Using head-restrained mice in a choice task based on action-outcome history, we show that many mPFC and DMS neurons represent the difference in reward history between options, a decision variable guiding advantageous choices. Crucially, mPFC encodes this variable earlier and more rapidly than DMS. Temporally targeted optogenetic interference with mPFC representation impairs decision-making. Moreover, functional connectivity between mPFC and DMS strengthens as the overall reward proportion declines. Our results support a framework in which the prefrontal cortex acts as the initial detector of inferred environmental changes, enhancing communication with the striatum to promote adaptive and flexible behavior.

Indexed as

Biological sciencesPlant biology

Identifiers

PMID41321636
PMCPMC12662081

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.