ArticleiScience2025
Domain-like patterning of dendritic asymmetry and orientation defined by gap junctions in the mouse retina.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal topology, along with dendritic arbor symmetry and orientation, are key morphological features that are closely linked to the visual functions of RGCs. tOFF-α RGCs are implicated in the detection of approaching motion, an essential visual cue for triggering innate escape responses. Here we demonstrate that dorsally and ventrally oriented tOFF-α dendritic arbors are preferentially found in the temporal and ventral-peripheral retinal regions, respectively. This spatial organization likely enhances sensitivity to objects approaching from above or behind. Notably, tOFF-α RGCs that are electrically coupled via GJs exhibit similar arbor asymmetry and orientation, forming distinct morphological clusters that are spatially segregated from neighboring arrays. These clusters suggest the existence of localized functional domains within the tOFF-α RGC population, potentially supporting a refined mechanism for direction-specific approach detection.
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Registered trials
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