Evidence map›Paper›PMID 41321598›Full record

ArticleSynthetic and systems biotechnology2026

High-level production of vitamin K2 in

Zelin Lu, Zhongshi Huang, Zhengyin Wu, Zhengwen Zhu, Yibo Zhu, Xiaonuo Teng, Huyang Chen, Jingwen Zhou, Fuqiang Ma, Xinglong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Menaquinone biosynthesis inEngineering microbiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zelin LuMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.
Zhongshi HuangMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.
Zhengyin WuMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.
Zhengwen ZhuMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.
Yibo ZhuSchool of Biological and Food Engineering, SuZhou University of Technology, 99 South Third Ring Road, Suzhou, Jiangsu Province, 215500, China.
Xiaonuo TengSuzhou Womei biology Co., Ltd., 2 Luoxiang Road, Suzhou, Jinagsu Province, 215600, China.
Huyang ChenSuzhou Womei biology Co., Ltd., 2 Luoxiang Road, Suzhou, Jinagsu Province, 215600, China.
Jingwen ZhouScience Center for Future Foods, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China.
Fuqiang MaMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.
Xinglong WangMedical Enzyme Engineering Center, CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 88 Keling Road, Suzhou, Jiangsu Province, 215004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Menaquinone-7 (MK-7), a key form of vitamin K2 with wide-ranging nutritional and pharmaceutical applications, has attracted increasing interest for microbial production. Here, we developed an integrated modular metabolic engineering strategy in

Indexed as

Enzyme engineeringFermentation optimizationIndustrial biosynthesisMenaquinone-7 (MK-7)

Identifiers

PMID41321598
PMCPMC12657337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.