ArticleFrontiers in veterinary science2025
Osteolytic metastases from a pheochromocytoma presenting as multiple limb lameness and joint swelling in a dog: a case report.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Clinical signs due to distant bony metastasis from a malignant pheochromocytoma are rare in dogs, with the majority of reported cases presenting as single-limb lameness. This case report describes a 6-year-old neutered male mixed-breed dog presenting with multiple limb lameness and joint swelling that occurred over 3 weeks. Computed tomography revealed a mass in the right adrenal gland with extensive intrathoracic, intra-abdominal, and skeletal metastases. Because of the poor prognosis, the dog was humanely euthanized. A postmortem examination revealed a primary neoplasm of the right adrenal gland with metastases affecting the contralateral adrenal gland, kidneys, lungs, liver, and bones of the appendicular and axial skeletons. Immunohistochemistry confirmed a metastatic neuroendocrine carcinoma of the right adrenal gland, consistent with a pheochromocytoma. This case is a unique presentation of polyostotic metastases from a pheochromocytoma and emphasizes the importance of including this tumor in the differential diagnosis of dogs presenting with symptoms identical to those of polyarthritis.
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