Evidence map›Paper›PMID 41321545›Full record

ArticleCase reports in ophthalmology

The Value of Detecting and Monitoring ctDNA in Uveal Melanoma: Results of a Pilot Study and a Systematic Review.

Fatemeh Azimi, Saeed Talebi, Reza Mirshahi, Golnaz Khakpoor, Masood Naseripour

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatemeh AzimiEye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Saeed TalebiDepartment of Medical Genetics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Reza MirshahiEye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Golnaz KhakpoorEye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Masood NaseripourEye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This article presents the results of a prospective pilot study on circulating tumor DNA (ctDNA) monitoring in uveal melanoma (UM) patients, along with a systematic review of the literature to support and contextualize the findings. We investigated the clinical utility of ctDNA variant allele frequency (VAF) for early detection of tumor progression. Case Presentations: We performed serial ctDNA testing using the Ion AmpliSeq Cancer Hotspot Panel v2 and Ion Proton™ sequencing in 3 UM patients (two recurrent, one nonrecurrent) at four time points over 2 years. A systematic review of studies up to June 2024 was also conducted, identifying 32 additional UM patients. In recurrent patients, co-occurring mutations in Conclusion: Serial ctDNA analysis may serve as a noninvasive tool for early detection of recurrence in UM. Co-occurrence of

Indexed as

Circulating tumor DNAPilot studySystematic reviewUveal melanomaVariant allele frequency

Identifiers

PMID41321545
PMCPMC12659632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.