Evidence map›Paper›PMID 41321523›Full record

ReviewAnimal nutrition (Zhongguo xu mu shou yi xue hui)2025

New insights into methionine's role in maintaining intestinal stem cell regeneration via autophagy regulation.

Yaxue Lv, Yuqing Feng, Jiandong Lu, Sheng Zhang, Yihan Wei, Chunqi Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yaxue LvGuangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yuqing FengGuangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jiandong LuGuangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Sheng ZhangGuangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yihan WeiCollege of Animal Science and Technology, State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100091, China.
Chunqi GaoGuangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an essential amino acid, methionine (Met) is crucial for several biological functions, including protein synthesis, cell proliferation, and protection against oxidative stress. As research uncovers the role of Met in addressing conditions like colorectal cancer and colitis, understanding its mechanisms in promoting gut health becomes increasingly vital. This review highlights the importance of intestinal stem cells (ISCs) in maintaining gut stability and discusses the impact of autophagy on these stem cells. Additionally, it provides a comprehensive examination of Met's biological characteristics, metabolic pathways, and its regulatory effects on autophagy. Met has promising potential for innovation in both nutritional and therapeutic contexts through its regulation of autophagy. By emphasizing its role in enhancing gut health and its therapeutic capabilities for related diseases, this article offers fresh perspectives for developing food products and pharmaceuticals, paving the way for more in-depth research and applications in this area.

Indexed as

AutophagyIntestinal homeostasisIntestinal stem cellMethionineNutritional regulation

Identifiers

PMID41321523
PMCPMC12657756

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.