Evidence map›Paper›PMID 41321503›Full record

ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2025

Terpine-4-ol alleviates lipopolysaccharide-induced intestinal injury in weaned piglets by regulating intestinal epithelial cell homeostasis via the Wnt/β-catenin signaling pathway.

Li Dong, Yangshu Zhou, Mengxuan Wang, Qingqing Yuan, Guangzhi Qiu, Jun Liu, Hongrong Wang, Aimin Wu, Lihuai Yu, Daiwen Chen

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In one paragraph

Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Li DongInstitute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Yangshu ZhouCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Mengxuan WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Qingqing YuanCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Guangzhi QiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Jun LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Hongrong WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Aimin WuInstitute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Lihuai YuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Daiwen ChenInstitute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to elucidate intestinal injury from the perspective of intestinal epithelial cell homeostasis and to explore the modulatory roles of terpine-4-ol (a major bioactive component of tea tree oil). Forty 28-day-old piglets (7.82 ± 0.43 kg) were randomly divided into 5 groups with 8 pigs per group. Piglets in the control (CON) and lipopolysaccharide (LPS) groups were fed a basal diet, while those in the remaining 3 groups were fed the basal diet supplemented with 30 (LTP), 60 (MTP), or 90 mg/kg terpine-4-ol (HTP), respectively. Piglets in the LPS and terpine-4-ol supplementation groups were intraperitoneally injected with 100 μg/kg BW of LPS at the end of the 21-day growth period. Six hours after injection, 6 piglets from each group were randomly selected and slaughtered to detect intestinal cell homeostasis. The results showed that the average daily weight gain (ADG) and average daily feed intake (ADFI) of piglets in MTP and HTP groups were higher than those in the CON group (

Indexed as

Intestinal stem cellIntestine epithelial cellPigletTerpine-4-olwingless-type MMTV integration site family/β-catenin signaling pathway

Identifiers

PMID41321503
PMCPMC12663521

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.