Evidence map›Paper›PMID 41321481›Full record

Trial reportDepression and anxiety2025

Music Therapy Modulates Abnormal Brain Networks and Alleviates Anxiety Symptoms in University Students: An fNIRS Study.

Lijuan Liang, Yue Zhu, Zhiguo Zheng, Hui Ma, Xuefeng Cai, Hua Yang, Fei Wang

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijuan LiangDepartment of Psychology, The First Affiliated Hospital of Hainan Medical University, Haikou, China.ORCID 0000-0002-1081-0520
Yue ZhuEarly Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.ORCID 0009-0004-5220-4176
Zhiguo ZhengSchool of Information Engineering, Hainan Vocational University of Science and Technology, Haikou, China.ORCID 0009-0004-3588-7729
Hui MaPsychological Counseling and Treatment Center, Hainan Provincial Anning Hospital, Haikou, China.ORCID 0000-0002-4307-3934
Xuefeng CaiPsychological Counseling and Treatment Center, Hainan Provincial Anning Hospital, Haikou, China.ORCID 0009-0009-5586-5240
Hua YangPsychological Counseling and Treatment Center, Hainan Provincial Anning Hospital, Haikou, China.ORCID 0009-0005-8681-9854
Fei WangEarly Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-5982-2303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety's prevalence is increasing, making it a widespread mental health concern. However, scale-based diagnostic methods have limitations. Music therapy helps regulate emotions and alleviate anxiety symptoms. Functional near-infrared spectroscopy (fNIRS) offers a novel approach to diagnosing mental disorders by measuring changes in the concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) in the superficial layers of the brain, thereby reflecting brain activation. This is the first study to use fNIRS to examine the impact of music therapy on anxiety. fNIRS was used to measure changes in HbO and HbR in the superficial brain regions of individuals with anxiety symptoms to evaluate music therapy effectiveness and identify brain regions associated with anxiety. This study recruited 83 participants: 17 comprised the healthy control group, and 66 comprised the anxiety group. The anxiety group was divided into an intervention group (34 participants) and a waiting-list group (32 participants). The intervention group underwent 12 music therapy sessions and exhibited significant changes compared with the waiting group. These changes included connectivity between Wernicke's area and the dorsolateral prefrontal cortex (DLPFC) as well as the visual association cortex and Broca's triangular area. These results suggested that the connectivity characteristics of these brain regions were associated with anxiety. Music therapy significantly improved brain network connectivity characteristics in individuals with anxiety symptoms. Furthermore, fNIRS indicators could serve as biomarkers for the auxiliary identification of anxiety symptoms, aiding early identification and intervention.

Indexed as

AnxietyBrainMusic TherapyNerve NetAdolescentAdultFemaleFunctional NeuroimagingHumansMaleSpectroscopy, Near-InfraredStudentsUniversitiesYoung Adultanxietybiomarkersbrain connectivityfunctional near-infrared spectroscopy (fNIRS)music therapy

Identifiers

PMID41321481
PMCPMC12660629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.