ArticleFrontiers in pediatrics2025
Immunological profile and its clinical implications in pediatric infectious mononucleosis.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- IL-10, IL-17A, and IFN-γ as clinical early-warning indicators for severe Epstein-Barr virus-associated infectious mononucleosis in children.BMC pediatrics · 2026Article
- Diagnostic value of combined flow cytometry-based detection of peripheral blood lymphocyte subsets and cytokines for pediatric infectious mononucleosis.Frontiers in pediatrics · 2026Article
- Alanine aminotransferase elevation in hospitalized children with infectious mononucleosis: independent associations with Epstein-Barr virus DNA load, age, and sex.Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To analyze the differences in peripheral blood immune function between children with infectious mononucleosis (IM) who developed liver injury (LI) and those non-liver injury (NLI), and to investigate the regulatory role of immune markers in IM infection. Methods: A total of 50 hospitalized children diagnosed with IM at Hangzhou Children's Hospital between November 2023 and August 2024 were enrolled as the Epstein-Barr Virus (EBV) infection group, including 19 without LI and 31 with LI. Additionally, 30 age-matched healthy children undergoing routine physical examinations during the same period were included as the control group. Flow cytometry was used to detect 12 cytokines, granzyme B (GzmB), perforin (PRF), regulatory T cells (Tregs), programmed cell death protein 1 (PD-1), and other immune markers in peripheral blood. CD100 levels were measured by ELISA. Results: The expression levels of IL-5, IFN-α, IL-2, IL-6, IL-10, IFN-γ, and IL-8 were significantly elevated in the EBV infection group compared to the control group ( Conclusion: EBV infection-induced IM is associated with abnormal expression of various immune markers in peripheral blood.The high expression of GzmB and low expression of CD28 are associated with LI in IM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.