ArticleCase reports in dentistry2025
Sequential Use of Apremilast, Total Glucosides of Paeony, and Periodontal Therapy in Refractory Plurimucosal Lichen Planus: A Case Report.
Article in Case reports in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lichen planus (LP) is a chronic inflammatory disorder affecting mucosa and skin. This report presents a 61-year-old female with refractory LP involving buccal, gingival, and vulvovaginal mucosa, unresponsive to prior therapies including corticosteroids and hydroxychloroquine. The patient was treated with apremilast, a phosphodiesterase-4 inhibitor, combined with total glucosides of paeony. Within 4 weeks with apremilast and total glucosides of paeony, the patient experienced significant clinical improvement, with reduced Investigator Global Assessment and reticulation-erythema-ulceration scores. Periodontal scaling and root planing were performed at 8 weeks, further enhancing oral health. At 14 and 20 months after treatment initiation, the patient's condition remained stable, with no significant adverse effects. This case suggests that sequential therapy with apremilast and total glucosides of paeony may be a promising option for managing refractory LP involving multiple mucosal sites. Strategically timed periodontal intervention, initiated after systemic control, improved tolerability and underscored the value of a sequential, multidisciplinary approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.