ArticleReproductive medicine and biology
Effects of Maternal Age on Receptivity and Pregnancy Outcomes of Single Euploid Transfers: A Retrospective Cohort Study.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Maternal Age on Receptivity and Pregnancy Outcomes of Single Euploid Transfers: A Retrospective Cohort Study.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Maternal age-related fertility decline is considered to be directly attributed to either embryonic or endometrial factors. Aneuploidy, as the dominant defect in aging embryos, has long diverted attention away from the effects of endometrial senescence. By analyzing the outcomes of euploid blastocyst transfers verified through preimplantation genetic testing for aneuploidy (PGT-A), we aimed to corroborate impaired endometrial receptivity among older women and determine whether the aging uterus also contributes to pregnancy maintenance. Methods: This is a single-center, real-world retrospective cohort study recruiting subfertile couples intended for PGT-A. We assessed the comprehensive correlations between maternal age and clinical outcomes, including clinical pregnancy and clinical miscarriage that represent distinct stages of pregnancy, as well as biochemical pregnancy, live birth, and maternal and neonatal events. Results: A total of 1816 subfertile couples intended for PGT-A were initially recruited, among whom 1376 obtained euploid blastocysts, leading to 2035 serial single frozen-thawed transfers. Baseline endometrial receptivity exhibited age-dependent impairment, as partially indicated by a reduction in thickness (9.409 ± 2.413 mm to 8.893 ± 2.286 mm; Conclusions: PGT-A, serving as an autologous model to control embryonic quality and study endometrial factors, seems feasible, although nonchromosomal and procedure-related factors may require further distinguishment. Advanced maternal age (AMA) is related to decreased receptivity, and endometrial aging is an independent determinant of euploid implantation. This message offers insights for profound research and appropriate counseling on AMA conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.