ArticleMatrix biology plus2025
Latent-Transforming growth factor - β Binding protein 1 (LTBP1) in corneal stroma.
Article in Matrix biology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
We aim to determine the presence and function of LTBP1 in the corneal stroma. We investigated the temporal and spatial corneal expression of LTBP1, and microfibril-associated glycoprotein 1 (MAGP1), known components of the elastic system and regulators of TGF-β storage and latency. Protein quantification -blotting and proteomics-, immunofluorescence microscopy, mRNA analysis and a luciferase assay were used to study the regulation of transforming growth factor β (TGF-β) by LTBP1 in cornea derived fibroblasts and myofibroblasts. Expression of LTBP1 and MAGP1 was found in adult corneas, and absent or minimal in the scleral stroma. Quantitative polymerase chain reaction and protein blotting analyses showed upregulation of these proteins during early postnatal development and deposition in the corneal matrix with tissue maturation. In vitro, LTBP1 regulated the conversion of fibroblasts to myofibroblasts and maintained TGF-β latent in the matrix. This study shows that LTBP1 and MAGP1, regulators of TGF-β activation and elastic fiber components, are found in adult stroma. LTBP1 is a regulator of TGF-β storage and latency and controls conversion of fibroblast to myofibroblast.
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