Trial reportInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
The impact of low-dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy.
Trial report in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Low-dose aspirin and anaemia risk in pregnancy: A scoping review with emphasis on low- and middle-income contexts.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study evaluates the association of low-dose aspirin (LDA) with hemoglobin (Hb) levels during pregnancy and explores how changes in Hb levels relate to hypertensive disorders of pregnancy (HDP).
methodsThis secondary analysis of a randomized controlled trial comprised 249 pregnant women recruited from a regional hospital in Durban, South Africa (SA). Participants were randomized to receive either 162 mg of LDA daily (intervention) or standard care (control). Hemoglobin levels were measured at enrolment and again at birth. Data on maternal outcomes, including HDP, were analyzed in relation to changes in Hb levels to assess potential associations.
resultsAt enrolment, the predominant Hb range was 9.0-10.9 g/dL (mild anemia) in 51.4% of participants, with comparable Hb distributions between groups. By birth, 43.4% remained mildly anemic, while 44.2% had normal Hb levels (11-13 g/dL). Among participants who experienced a decline in Hb, the reduction was significantly mitigated in the intervention compared to the control group (ΔHb = -0.902 vs. -1.422, P = 0.002, η
conclusionLow-dose aspirin was associated with a smaller decline in Hb levels and lower HDP risk; consistent with a potential hematological benefit beyond preeclampsia prevention, although this represents an association rather than causation. Hemoglobin reduction might also serve as an early predictor of HDP.
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