Evidence map›Paper›PMID 41321289›Full record

Trial reportInternational endodontic journal2026

Randomised Controlled Trial on the Additive Effect Between Calcium Hydroxide and Sodium Hypochlorite in an Inter-Visit Root Canal Dressing.

Nidambur V Ballal, Namith Rai, Padmaja A Shenoy, Vibha Acharya, Vinutha R Bhat, Matthias Zehnder

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nidambur V BallalDepartment of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0002-2208-9443
Namith RaiDepartment of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0002-7454-6300
Padmaja A ShenoyDepartment of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0001-6781-5579
Vibha AcharyaDepartment of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0009-0003-0910-659X
Vinutha R BhatDepartment of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0002-9457-9492
Matthias ZehnderUniversity of Zurich, Clinic of Conservative and Preventive Dentistry, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-9545-7828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess whether there was an additive antimicrobial effect between calcium hydroxide (Ca(OH) METHODOLOGY: Patients presenting with a single-rooted tooth with pulpal necrosis and asymptomatic apical periodontitis were included in this randomised controlled single-center clinical superiority trial with two parallel arms. Teeth were instrumented using a rotary file system and irrigated with 3% NaOCl. Subsequently, the root canals were dressed with a Ca(OH)

resultsFrom the 110 patients recruited for this study, 48 were available for all three sampling procedures in the test (NaOCl) and 50 in the control (saline) group. All canals showed anaerobic growth initially. Chemo-mechanical instrumentation significantly reduced CFU counts (p < 0.001), yet all canals remained growth-positive. After dressing with Ca(OH)

conclusionsPlacing a combined NaOCl/Ca(OH) TRIAL REGISTERATION: CTRI/2020/10/028484 (Clinical Trials Registry India).

Indexed as

Calcium HydroxidePeriapical PeriodontitisRoot Canal IrrigantsRoot Canal TherapySodium HypochloriteAdultDental Pulp CavityDental Pulp NecrosisFemaleHumansMaleMiddle AgedRoot Canal PreparationCalcium HydroxideRoot Canal IrrigantsSodium Hypochloriteapical periodontitiscalcium hydroxidedisinfectionroot canalsodium hypochlorite

Identifiers

PMID41321289
PMCPMC12884262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.