Evidence map›Paper›PMID 41321237›Full record

ArticlePharmacology research & perspectives2025

Effect of Thrombopoietin Receptor Agonist Romiplostim on the Ionizing Radiation-Induced Premature Aging.

Masaru Yamaguchi, Tokuhisa Hirouchi, Yoshiaki Sato, Ikuo Kashiwakura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Masaru YamaguchiDepartment of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.
Tokuhisa HirouchiDepartment of Radiobiology, Institute for Environmental Sciences, Rokkasho, Japan.
Yoshiaki SatoNorris Comprehensive Cancer Center, University of Southern California, California, Los Angeles, USA.ORCID 0000-0003-3375-5189
Ikuo KashiwakuraDepartment of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.

Funding

Japan Society for the Promotion of Science JP16H02667
6 · The paper itself

Abstract

Environmental stressors, such as ionizing radiation, accelerate aging by causing DNA damage and triggering pathways that lead to cell cycle arrest, apoptosis, and subsequent inflammation. The thrombopoietin receptor agonist romiplostim (RP), which is used as a clinical treatment for chronic idiopathic thrombocytopenic purpura and aplastic anemia, is known to be promising in reducing radiation-induced tissue damage. In this study, we established a mouse model of radiation-induced premature aging to evaluate the potential of RP in ameliorating this process. Female C57BL/6JJcl mice were subjected to total body irradiation with various irradiation schedules. Mice irradiated with 5 Gy every 4 weeks (total dose of 10 Gy over 2 months) showed a significant aging phenotype, including graying hair and elevated serum aging markers (CDKN2A/p16

Indexed as

Aging, PrematureReceptors, FcReceptors, ThrombopoietinRecombinant Fusion ProteinsThrombopoietinAnimalsC-Reactive ProteinFemaleMiceMice, Inbred C57BLRadiation, IonizingTumor Necrosis Factor-alphaWhole-Body IrradiationC-Reactive ProteinReceptors, FcReceptors, ThrombopoietinRecombinant Fusion ProteinsromiplostimThrombopoietinTumor Necrosis Factor-alphamouse modelradiation‐induced premature agingromiplostimtotal body radiation

Identifiers

PMID41321237
PMCPMC12666149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.