Evidence map›Paper›PMID 41321195›Full record

ArticleClinical pharmacology and therapeutics2026

An Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub-Saharan African Ancestry.

Akinyemi Oni-Orisan, Sook Wah Yee, Tanushree Haldar, Michelle Whirl-Carrillo, Kelly Caudle, Deepak Voora, Richard B Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akinyemi Oni-OrisanDepartment of Clinical Pharmacy, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-5897-5543
Sook Wah YeePharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut, USA.ORCID 0000-0001-8121-8746
Tanushree HaldarDepartment of Clinical Pharmacy, University of California San Francisco, San Francisco, California, USA.
Michelle Whirl-CarrilloDepartment of Biomedical Data Science, Stanford University, Stanford, California, USA.ORCID 0000-0003-2414-9312
Kelly CaudleDepartment of Pharmaceutical Sciences and Pharmacy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-5663-3793
Deepak VooraVA National Pharmacogenomics Program, Department of Veteran's Affairs, Durham, North Carolina, USA.ORCID 0000-0003-0015-5179
Richard B KimDepartment of Medicine, Western University, London, Ontario, Canada.ORCID 0000-0001-8148-1632

Funding

Genetic and social determinants of pharmacological health outcomes in ancestrally diverse populations (Warren)R01HG012824 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Akinyemi Oni-Orisan · 2023 to 2026
$2.4M
NHGRI NIH HHS R01 HG012824
6 · The paper itself

Abstract

The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research. This perspective illustrates how new evidence can advance clinical pharmacogenetics implementation guidelines incorporation in real time through collaboration with CPIC. Together, we can accelerate the translation of pharmacogenetics into a tool that truly improves health outcomes for everyone.

Indexed as

Black PeopleLiver-Specific Organic Anion Transporter 1PharmacogeneticsAfrica South of the SaharaAllelesHumansLiver-Specific Organic Anion Transporter 1SLCO1B1 protein, human

Identifiers

PMID41321195
PMCPMC13055011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.