Evidence map›Paper›PMID 41321079›Full record

ArticleChembiochem : a European journal of chemical biology2026

Differentiating the Substrate Profiles of Inflammatory Caspases Using Extended Förster Resonance Energy Transfer-Based Peptide Substrates.

Tess C Boyd, Sophie F Young, Tessa L Lusis, Mya A Fegaras, Rifqa Alani, Kaitlyn Shelley, Cathrine A Southern, Caitlin E Karver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tess C BoydDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Sophie F YoungDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Tessa L LusisDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Mya A FegarasDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Rifqa AlaniDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Kaitlyn ShelleyDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Cathrine A SouthernDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.
Caitlin E KarverDepartment of Chemistry and Biochemistry, DePaul University, 1110 W Belden Avenue, Chicago, IL, 60614, USA.ORCID https://orcid.org/0000-0003-1249-7395

Funding

Uncovering the biological roles of inflammatory caspases through chemical approachesR15GM132990 · NIGMS · DE PAUL UNIVERSITY · PI KARVER, CAITLIN E., SOUTHERN, CATHRINE ANN · 2020 to 2020
$438k
NIGMS NIH HHS R15 GM132990NIH HHS 1R15GM132990-01A1
6 · The paper itself

Abstract

Human inflammatory caspases (caspase-1, -4, and -5) are key players in the innate immune response. These enzymes have been shown to cleave proinflammatory substrates, implicating them in many inflammatory disease states. Their activity is frequently assessed using in vitro fluorogenic assays, with all three human inflammatory caspases preferring the same WEHD tetrapeptide. The study examines the specificity of these enzymes C-terminal to the cleaved aspartate residue with Förster resonance energy transfer peptide-based assays using 7-methoxycoumaryl alanine [A(MCA)] as the donor and lysine-conjugated dabsyl [K(Dab)] as the quencher. The P

Indexed as

CaspasesFluorescence Resonance Energy TransferInflammationPeptidesAmino Acid SequenceHumansSubstrate SpecificityCaspasesPeptidescaspasesenzymesFörster resonance energy transfer assayinflammationpeptides

Identifiers

PMID41321079
PMCPMC12695177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.