Evidence map›Paper›PMID 41321078›Full record

ArticleBJPsych open2025

Mental Health Intervention for Children with Epilepsy (MICE): cost-effectiveness analysis of psychological therapy in addition to usual care compared with assessment-enhanced usual care alone for children and young people with epilepsy and common mental health disorders.

Poushali Ganguli, Sophie D Bennett, Kashfia Chowdhury, J Helen Cross, Bruce Chorpita, Anna E Coughtrey, Emma Dalrymple, Peter Fonagy, Tamsin Ford, Isobel Heyman and 9 more

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Article in BJPsych open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Poushali GanguliInstitute of Psychiatry, Psychology & Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.ORCID https://orcid.org/0000-0002-1764-5273
Sophie D BennettInstitute of Psychiatry, Psychology & Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Kashfia ChowdhuryComprehensive Clinical Trials Unit, University College London, London, UK.
J Helen CrossUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Bruce ChorpitaDepartment of Psychology, University of California Los Angeles, Los Angeles, California, USA.
Anna E CoughtreyUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Emma DalrympleUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Peter FonagyDivision of Psychology & Language Sciences, University College London, London, UK.
Tamsin FordDepartment of Psychiatry, Cambridge University, Cambridge, UK.ORCID https://orcid.org/0000-0001-5295-4904
Isobel HeymanUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Rona Moss-MorrisInstitute of Psychiatry, Psychology & Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
Terence StephensonUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Anaïs d'OelsnitzUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Mariam ShahUniversity College London Great Ormond Street Institute of Child Health, London, UK.
James BlackstoneComprehensive Clinical Trials Unit, University College London, London, UK.ORCID https://orcid.org/0000-0003-4335-5269
Harriet QuartlyComprehensive Clinical Trials Unit, University College London, London, UK.
MICE Consortium
Roz ShafranUniversity College London Great Ormond Street Institute of Child Health, London, UK.
Sarah ByfordInstitute of Psychiatry, Psychology & Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.ORCID https://orcid.org/0000-0001-7084-1495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMental health issues are prevalent among children and young people (CYP) with chronic conditions like epilepsy, yet few access evidence-based psychological therapies. Evidence from the Mental Health Intervention for Children with Epilepsy (MICE) trial supports the effectiveness of a personalised modular psychological intervention, but cost-effectiveness is unknown.

aimsTo assess the cost-effectiveness of the MICE intervention compared with assessment-enhanced usual care at 12-months follow-up, taking a health and social care perspective.

methodWe conducted a within-trial economic evaluation. Outcomes were the Strengths and Difficulties Questionnaire (SDQ; primary) and quality-adjusted life years (QALYs; secondary) for CYP, caregivers, and CYP and caregivers combined. Sensitivity analyses examined missing data and intervention-costing assumptions.

resultsCost-effectiveness results for the SDQ indicated that MICE had a higher probability of being cost-effective compared with control at a willingness to pay ≥£368 per unit improvement. For QALYs, MICE had a lower probability of being cost-effective for CYP compared with control (35 to 42%) across the £20 000-£30 000 per QALY threshold range. However, at the upper threshold this finding was reversed in sensitivity analyses with missing data imputed (45 to 58%) and with MICE costed at 75%, assuming the intervention partly substituted standard services (46 to 55%). Furthermore, MICE had a higher probability of being cost-effective for caregiver QALYs (52 to 63%) and combined CYP and caregiver QALYs (62 to 75%).

conclusionsMICE appears to be cost-effective compared with assessment-enhanced usual care when considering QALYs for CYP and caregivers combined, though uncertainty exists across willingness-to-pay thresholds.

Indexed as

Child and adolescent psychiatrychildhood epilepsyeconomic evaluationepidemiologyevidence-based mental health

Identifiers

PMID41321078
PMCPMC12724111

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.