Evidence map›Paper›PMID 41320783›Full record

ReviewMedical physics2025

Seeing the invisible: In vivo dosimetry in radiotherapy with radiacoustic IMAGING.

Kristina Bjegovic, Lei Ren, Yong Chen, Emil Schüler, Lei Xing, Shawn Liangzhong Xiang

Abstract readReview
In one paragraph

Review in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristina BjegovicThe Department of Biomedical Engineering, University of California, Irvine, USA.
Lei RenDepartment of Radiation Oncology Physics, University of Maryland, Baltimore, USA.
Yong ChenDepartment of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Emil SchülerDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA.
Lei XingDepartment of Radiation Oncology, Stanford University, Palo Alto, USA.
Shawn Liangzhong XiangThe Department of Biomedical Engineering, University of California, Irvine, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation TherapyR37CA240806 · NCI · UNIVERSITY OF OKLAHOMA · PI CHEN, YONG, IVANOV, VASSILI · 2019 to 2025
$2.9M
3-dimensional prompt gamma imaging for online proton beam dose verificationR01CA279013 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Jerimy C. Polf, Lei Ren · 2023 to 2026
$1.9M
3D In vivo dosimetry for FLASH proton therapyU01CA288351 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Yong Chen, Lei Ren · 2024 to 2026
$1.8M
Quantitative in vivo dosimetry for radiotherapy using model-based X-ray-induced acoustic computed tomographyR50CA283816 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Prabodh Kumar Pandey · 2024 to 2026
$317k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA279013NCI NIH HHS R37 CA240806NCI NIH HHS R50 CA283816NCI NIH HHS U01 CA288351NIH HHS R01CA279013NIH HHS R37CA240806NIH HHS R50CA283816NIH HHS U01CA288351UCI Chao Family Comprehensive Cancer Center P30CA062203
6 · The paper itself

Abstract

Radiation therapy is a cornerstone of cancer management, utilized in over half of all cancer treatments. Treatment precision is critical for ensuring the efficacy of radiation therapy. Current radiotherapy modalities-x-ray photon, proton, and electron therapies-each offer distinct advantages and challenges depending on tumor characteristics and treatment goals. Despite technological advancements in treatment planning and image guidance, challenges such as intra-fractional and inter-fractional tumor motion and the lack of in vivo dose verification persist. Radiacoustic imaging (RAI) has emerged as a promising solution for real-time in vivo dose verification and adaptive radiotherapy. By detecting acoustic waves generated during radiation dose deposition, RAI offers the potential to enhance treatment precision and outcomes. This review explores the development, performance, and clinical applications of RAI, particularly its utility across photon, proton, and electron therapies, as well as its potential in FLASH radiotherapy. We also discuss its future prospects, projecting its integration into clinical workflows and its role in transforming cancer treatment.

Indexed as

RadiometryRadiotherapy, Image-GuidedHumansNeoplasmsFLASH dosimetryradiacousticsradiation dosimetry

Identifiers

PMID41320783
PMCPMC12767473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.