ArticleAngewandte Chemie (International ed. in English)2026
Acid- and Nucleophile-Gated Photoisomerization of Phosphaindirubin.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Reversible 900 nm Near-Infrared Photoswitch for Invisibly Writable 2D and 3D Displays.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Nature uses protonation and microenvironmental effects to modulate photoisomerization, as seen in rhodopsins and GFP. Inspired by this, we report phosphaindirubin (PI), a visible-light responsive photoswitch bearing a stereogenic phosphorus center that exhibits reversible Z/E isomerization controlled by light, acid, and nucleophiles. While structurally related to photoinert isoindigo, phosphaindirubin undergoes efficient Z→E isomerization in low-polarity solvents but remains inert in polar media unless protonated. Acid gating alters the excited-state landscape, enabling switching under light irradiation in acetonitrile. Strikingly, the thermal back-isomerization of PI is accelerated by nucleophiles, including pyridine and iodide, offering an underexplored mechanism for catalyzing double bond rotation. This triple-responsiveness to light, acid, and nucleophile enables reversible, fatigue-resistant cycling between Z- and E-forms. These findings introduce a new design principle for photoswitches based on dynamic, multi-stimuli gating of excited-state and ground-state reactivity.
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