Evidence map›Paper›PMID 41320681›Full record

ReviewMedical oncology (Northwood, London, England)2025

Regulatory roles of MKP7/DUSP16 in cancer.

Shiqi Chen, Maryam Mohammed Abbas Karekad, Jiaxi Yan, Linfeng Qian, Xuanwei Wu, Xiaoai Lv, Xiaohong Xu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Microorganisms · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiqi Chen *The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Maryam Mohammed Abbas Karekad *The International Education College of Zhejiang Chinese Medical University, Hangzhou, China.
Jiaxi YanThe First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Linfeng QianThe First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Xuanwei WuThe First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China.
Xiaoai LvThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Xiaohong XuThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China. 20163329@zcmu.edu.cn.

Funding

Guizhou Provincial Science and Technology Cooperation Foundation ZK(2025) General 023,Bingtuan Science and Technology Program No.2024ZD059Natural Science Foundation of Zhejiang Province KLZ25H290002
6 · The paper itself

Abstract

Mitogen-activated protein kinase phosphatases (MKPs), also known as dual-specificity phosphatases (DUSPs), are key regulatory factors within the mitogen-activated protein kinase (MAPK) pathway. MKP7/DUSP16, a member of the MKP family, has been identified in vitro as a phosphatase with specificity for p38 mitogen-activated protein kinase (p38) and c-jun amino-terminal kinase (JNK), with a stronger inhibitory effect on JNK compared to other MAPKs. In recent years, MKP7/DUSP16 has recently attracted increasing interest, with accumulating evidence suggesting its dysfunction is correlated with the progression and drug resistance of various cancers, making it a potential prognostic biomarker. However, research into the specific mechanisms by which MKP7/DUSP16 regulates cancer cells remains limited. Current studies suggest that MKP7/DUSP16 may promote cancer progression through the regulation of the MAPK pathway, mitochondrial apoptosis pathways, and the induction of cancer cell proliferation by immune cells. This review summarizes the mechanisms by which MKP7/DUSP16 may promote tumor proliferation. Further studies are needed to clarify its specific regulatory roles in cancer.

Indexed as

Dual-Specificity PhosphatasesMitogen-Activated Protein Kinase PhosphatasesNeoplasmsAnimalsApoptosisCell ProliferationHumansMAP Kinase Signaling SystemDual-Specificity PhosphatasesDUSP16 protein, humanMitogen-Activated Protein Kinase PhosphatasesImmuneMitochondrial apoptosis pathwaysMitogen-activated protein kinase (MAPK)Mitogen-activated protein kinase phosphatases (MKPs)MKP7/DUSP16

Identifiers

PMID41320681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.