Evidence map›Paper›PMID 41319721›Full record

ArticleInternational journal of radiation oncology, biology, physics2026

Enhanced Antitumor Efficacy of

Carolina A Ferreira, Hemanth K Potluri, Ahmed A Tantawy, Christopher F Massey, Joseph J Grudzinski, Amanda M Carston, Nathan B Clemons, Malick Bio Idrissou, Anna S Thickens, Zachary T Rosenkrans and 10 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Carolina A FerreiraDepartments of Radiology, Pharmacology and Toxicology and Biomedical Engineering, Michigan State University, East Lansing, Michigan.
Hemanth K PotluriDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.
Ahmed A TantawyComparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.
Christopher F MasseyDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Joseph J GrudzinskiDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Amanda M CarstonDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Nathan B ClemonsDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Malick Bio IdrissouDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Anna S ThickensDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Zachary T RosenkransDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Cynthia ChoiPharmaceutical Sciences Program, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin.
Caroline P KerrDepartment of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Anatoly N PinchukDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Ohyun KwonDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Justin J JefferyCarbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Bryan P BednarzDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Departments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Zachary S MorrisDepartment of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Jamey P WeichertDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin; Departments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Douglas G McNeelDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Reinier HernandezDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Departments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: hernandez6@wisc.edu.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MORRIS, ZACHARY SCOTT, WEICHERT, JAMEY P · 2020 to 2024
$12.5M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
UW SPECT/CT AcquisitionS10OD028670 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEICHERT, JAMEY P · 2020 to 2020
$598k
Targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy responseF30CA268780 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KERR, CAROLINE PAULA ANNE · 2022 to 2025
$145k
NCI NIH HHS F30 CA268780NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520NIGMS NIH HHS T32 GM140935NIH HHS S10 OD028670
6 · The paper itself

Abstract

purposeMany men with prostate cancer (PCa) develop metastatic castration-resistant PCa (mCRPC) after current treatment, which has a death rate of more than 50%. Although many approaches target mCRPC and show promising results, mCRPC is still incurable. Therefore, we aimed to investigate the efficacy and dosimetry of α ( METHODS AND MATERIALS: NM600 was radiolabeled with

resultsBoth

conclusions

Indexed as

ActiniumLutetiumProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantRadioisotopesRadiopharmaceuticalsAnimalsCell Line, TumorDisease Models, AnimalMaleMiceSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionActiniumActinium-225LutetiumLutetium-177RadioisotopesRadiopharmaceuticals

Identifiers

PMID41319721
PMCPMC12973509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.