Evidence map›Paper›PMID 41319339›Full record

ArticleChemMedChem2026

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi.

Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cristiane Aparecida FrancoLaboratory of Natural Product Chemistry and Organic Synthesis, Department of Chemistry, Universidade Federal de Viçosa, Avenida PH Rolfs s/n, Viçosa, 36570-900, Brazil.
Jodieh Oliveira Santana VarejãoLaboratory of Natural Product Chemistry and Organic Synthesis, Department of Chemistry, Universidade Federal de Viçosa, Avenida PH Rolfs s/n, Viçosa, 36570-900, Brazil.
Isabela Penna CeravoloLaboratory of Immunopathology, Fundação Oswaldo Cruz (FIOCRUZ), René Rachou Institute (IRR), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Victória Miranda MachadoLaboratory of Immunopathology, Fundação Oswaldo Cruz (FIOCRUZ), René Rachou Institute (IRR), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Antoniana Ursine KrettliLaboratory of Immunopathology, Fundação Oswaldo Cruz (FIOCRUZ), René Rachou Institute (IRR), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Daniela de Melo ResendeLaboratory of Functional Genomics of Parasites, Fundação Oswaldo Cruz (FIOCRUZ), René Rachou Institute (IRR), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Silvane Maria Fonseca MurtaLaboratory of Functional Genomics of Parasites, Fundação Oswaldo Cruz (FIOCRUZ), René Rachou Institute (IRR), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Felipe Terra MartinsInstitute of Chemistry, Universidade Federal de Goiás, Avenida Esperança, sn, Samambaia, Goiânia, 690-900, Brazil.
Eduardo Jorge PilauLaboratory of Biomolecules and Mass Spectrometry, Universidade Estadual de Maringá, Paraná, 87020-900, Brazil.
Vinícius Ribeiro MontesLaboratory of Biomolecules and Mass Spectrometry, Universidade Estadual de Maringá, Paraná, 87020-900, Brazil.
Markus KohlhoffLaboratory of Natural Products Chemistry, Fundação Oswaldo Cruz (FIOCRUZ), Avenida Augusto de Lima, 1715, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Eduardo V V VarejãoLaboratory of Natural Product Chemistry and Organic Synthesis, Department of Chemistry, Universidade Federal de Viçosa, Avenida PH Rolfs s/n, Viçosa, 36570-900, Brazil.ORCID https://orcid.org/0000-0002-1830-725X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 401785/2023-8Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01414-24
6 · The paper itself

Abstract

Herein, the synthesis and biological evaluation of hypofuran B and a series of analogs against Trypanosoma cruzi and Plasmodium falciparum is described. The compounds are obtained through crossed aldol condensation between phenylacetaldehyde and furfural derivatives, using reaction conditions optimized according to the aromatic substituents. Yields ranged from 20% to 83%, with E/Z ratios between 89:11 and 98:2. Three compounds are isolated as single crystals suitable for X-ray diffraction, and their crystal structures are determined. The most active analogs showed IC

Indexed as

AntimalarialsPlasmodium falciparumTrypanosoma cruziAnimalsCell LineCell SurvivalCrystallography, X-RayDose-Response Relationship, DrugMiceMolecular StructureParasitic Sensitivity TestsStructure-Activity RelationshipAntimalarials5‐HMFchagas diseasefurfuralmalarianeglected tropical diseases

Identifiers

PMID41319339
PMCPMC12811995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.