Evidence map›Paper›PMID 41319305›Full record

ArticleFEBS open bio2026

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems.

Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vanessa PointAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Wafaa AchacheAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Janïs LaudouzeAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Eliana Sepulveda RamosAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Mickaël MazieroAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Céline CrausteIBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Stéphane CanaanAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.ORCID https://orcid.org/0000-0001-7478-300X
Pierre SantucciAix Marseille Univ CNRS, LISM, IMM FR3479, IM2B, Marseille, France.ORCID https://orcid.org/0000-0002-6291-3425

Funding

Agence Nationale de la Recherche ANR-24-CE15-2633Agence Nationale de Recherches sur le Sida et les Hépatites Virales Project n°ANRS0358Aix-Marseille UniversitéFEBS Excellence AwardInitiative d'Excellence d'Aix-Marseille Université - A*MIDEX - IM2B AMX-19-IET-006Institut des sciences biologiques
6 · The paper itself

Abstract

The genetic basis underlying nontuberculous mycobacteria (NTM) pathogenesis remains poorly understood. This gap in knowledge has been partially filled over the years through the generation of novel and efficient genetic tools, including the recently developed CRISPR interference (CRISPRi) technology. Our group recently capitalized on the well-established mycobacteria-optimized dCas9

Indexed as

CRISPR-Cas SystemsNontuberculous MycobacteriaBacterial ProteinsCell DivisionGene SilencingMycobacterium abscessusMycobacterium smegmatisBacterial Proteinsgene silencingglycopeptidolipidsMmpL proteinsphenotypic assays

Identifiers

PMID41319305
PMCPMC13327033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.