Evidence map›Paper›PMID 41319286›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Delta Opioid Receptors within the Cortico-Thalamic Circuitry Underlie Hyperactivity Induced by High-Dose Morphine.

Chun-Yue Li, Huiqian Huang, Xiao-Fan Shen, Ke-Lei Cao, Di Zheng, Yi Zhu, Shi-Ze Xie, Xiao-Dan Yu, Hao Wang, Jia-Dong Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chun-Yue LiDepartment of Psychiatry of the Second Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Huiqian HuangDepartment of Psychiatry of the Second Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Xiao-Fan ShenNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Ke-Lei CaoNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Di ZhengNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Yi ZhuNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Shi-Ze XieNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Xiao-Dan YuNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Hao WangNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Jia-Dong ChenNHC and CAMS Key Laboratory of Medical Neurobiology, Ministry of Education Frontier Science Center for Brain Research and BrainMachine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Jie ShiNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, 100191, China.
Yue LiState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, 200032, China.
Min YanDepartment of Anesthesiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Xiao-Ming LiDepartment of Psychiatry of the Second Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-8617-1702

Funding

Fundamental Research Funds for the Central Universities 2025ZFJH01-01Fundamental Research Funds for the Central Universities 226-2024-00133Key Research and Development Program of Zhejiang Province 2024C03091Key Research and Development Program of Zhejiang Province 2024SSYS0017Nanhu Brain-computer Interface Institute 010904013National Natural Science Foundation of China 3220081National Natural Science Foundation of China 82071227National Natural Science Foundation of China 82090031National Natural Science Foundation of China 82288101National Natural Science Foundation of China 82371217National Natural Science Foundation of China U23A20433Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2023-PT310-01STI2030-Major Projects 2021ZD0202700Zhejiang Provincial Natural Science Foundation of China LR25C090001
6 · The paper itself

Abstract

Hyperactivity is a well-documented neurobehavioral effect of morphine and other opioid drugs, predominantly observed in rodent models, yet the neural circuits and molecular mechanisms underlying this effect remain elusive. In this study, an excitatory projection from the cingulate cortex (Cg) to the intermediate rostrocaudal division of zona incerta (ZIm) is revealed that is activated by morphine in mice. Chemogenetic inhibition of the Cg-ZIm pathway decreased high-dose (10-15mg kg

Indexed as

Cerebral CortexHyperkinesisMorphineReceptors, Opioid, deltaThalamusAnalgesics, OpioidAnimalsGyrus CinguliMaleMiceMice, Inbred C57BLAnalgesics, OpioidMorphineReceptors, Opioid, deltacingulate cortexdelta opioid receptorshyperactivitymorphinezona incerta

Identifiers

PMID41319286
PMCPMC12904023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.