ArticlePhysiological reports2025
Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cardioprotective effects of acetate supplementation against fructose-induced cardiac injury in pregnant Wistar rats.Current research in physiology · 2026Article
- Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats.Physiological reports · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Archaeological and anthropological evidence suggests that human ancestors' diets were rich in fiber, potassium, and complex carbohydrates, while low in sodium, refined sugars, and energy density. Over time, agroindustrialization led to diets poorer in fiber and micronutrients but higher in sodium, simple sugars, and calorie-dense foods. This shift contributed to the rise of noncommunicable diseases (NCDs) such as obesity, type 2 diabetes, and cardiovascular diseases, which now account for 70% of global premature deaths. Maternal nutrition affects fetal development and long-term health. High sucrose or fructose intake during pregnancy can alter placental function, impacting fetal growth and metabolism. Placentae from male and female fetuses may respond differently to maternal diet. However, the effects of excessive maternal fructose intake on the placenta and offspring remain underexplored. In this study, rat dams consuming fructose-sweetened beverages ate less food but drank more, significantly impacting placental volume and vascular structure. Long-term effects on offspring were sex-specific: females showed greater water retention and liver fat accumulation. High maternal fructose intake altered placental anatomy and had sex-specific effects on kidney and liver function in adult offspring, even without further fructose exposure. These findings highlight the importance of maternal diet in preventing future metabolic diseases.
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