Evidence map›Paper›PMID 41319212›Full record

ArticleJournal of medicinal chemistry2025

Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase Furin.

Roman W Lange, Charlotte Boller, Michael Loresch, Konstantin Bloch, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O Dahms, Torsten Steinmetzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roman W LangeInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 10, D-35032 Marburg, Germany.ORCID 0009-0004-7752-6403
Charlotte BollerInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 10, D-35032 Marburg, Germany.ORCID 0009-0003-1414-5980
Michael LoreschInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 10, D-35032 Marburg, Germany.
Konstantin BlochInstitute of Virology, Philipps University, Hans-Meerwein-Str. 2, 35043 Marburg, Germany.
Eva Böttcher-FriebertshäuserInstitute of Virology, Philipps University, Hans-Meerwein-Str. 2, 35043 Marburg, Germany.
Hans BrandstetterDepartment of Biosciences and Medical Biology, Structural Biology Lab, Paris Lodron University, Hellbrunner Straße 34, A-5020 Salzburg, Austria.
Sven O DahmsDepartment of Biosciences and Medical Biology, Structural Biology Lab, Paris Lodron University, Hellbrunner Straße 34, A-5020 Salzburg, Austria.ORCID 0000-0002-0915-7579
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 10, D-35032 Marburg, Germany.ORCID 0000-0001-6523-4754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proprotein convertase (PC) furin emerged as promising drug target for the treatment of numerous infectious diseases, cancer and cystic fibrosis. A recently described nonpeptidic lead structure served as template to develop a new series of PC inhibitors containing a dichlorobiphenyl-derived core segment decorated with a left and right inhibitor arm. The compounds were tested for their inhibitory potency against furin and the structurally related PC7. The most potent compounds inhibited furin with

Indexed as

Antiviral AgentsBiphenyl CompoundsDrug DesignFurinAnimalsCrystallography, X-RayHumansModels, MolecularStructure-Activity RelationshipAntiviral AgentsBiphenyl CompoundsFurin

Identifiers

PMID41319212
PMCPMC12703725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.