Evidence map›Paper›PMID 41319126›Full record

ArticleJournal of cardiovascular electrophysiology2026

Cost-Utility Analysis of Left Bundle Branch Area Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Multicenter, Prospective, Quasi-Experimental Study.

José M Sánchez-Moreno, Leticia García-Mochón, Manuel Molina-Lerma, Guillermo Gutiérrez-Ballesteros, Manuel Frutos-López, Ricardo Pavón-Jiménez, M C Olvera-Porcel, Juan Jiménez-Jáimez, Miguel Álvarez

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

José M Sánchez-MorenoUniversidad de Granada, Granada, Spain.ORCID 0000-0002-2087-718X
Leticia García-MochónUniversidad de Granada, Granada, Spain.
Manuel Molina-LermaUnidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Guillermo Gutiérrez-BallesterosUnidad de Arritmias, Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.ORCID 0000-0002-0121-214X
Manuel Frutos-LópezUnidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Ricardo Pavón-JiménezUnidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen de Valme, Sevilla, Spain.
M C Olvera-PorcelUnidad de Gestión y Apoyo a la Investigación, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Juan Jiménez-JáimezUniversidad de Granada, Granada, Spain.ORCID 0000-0001-5541-898X
Miguel ÁlvarezUnidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen de las Nieves, Granada, Spain.ORCID 0000-0002-0909-0749

Funding

Funding for open access charge: Universidad de Granada/CBUA. The authors received no specific funding for this work.
6 · The paper itself

Abstract

introductionCardiac resynchronization therapy (CRT) is a well-established treatment for patients with heart failure (HF). Recently, left bundle branch area pacing (LBBAP) has emerged as a more physiological alternative to biventricular pacing (BVP) for CRT. This study aimed to evaluate the cost-utility of LBBAP CRT compared with BVP CRT.

methodsA cost-utility, non-randomized, prospective, multicenter, quasi-experimental study was performed in four referral centers. Patients eligible for CRT were treated with LBBAP or BVP, depending on the participating center. The primary health outcome was quality-adjusted life years (QALYs) measured using the EQ-5D-5L questionnaire, and the analysis considered the cost of the implant and all procedure-related events over the 12-month follow-up. Clinical outcomes were also evaluated.

resultsSixty-two consecutive patients were included (42 LBBAP CRT and 20 BVP CRT). Clinical outcomes were similar in both groups. The incremental cost-utility analysis showed that LBBAP CRT generated an average cost saving of €2391.02 per patient compared with BVP (95% CI -330.28 to 5112.69), while providing an incremental gain of 0.07 QALYs (95% CI -0.03 to 0.16).

conclusionsLBBAP CRT could be an efficient alternative to BVP CRT for cardiac resynchronization with similar clinical and QALY outcomes but potentially significant average cost savings per patient.

Indexed as

Bundle of HisCardiac Resynchronization TherapyHealth Care CostsHeart FailureAgedCardiac Resynchronization Therapy DevicesCost-Benefit AnalysisCost SavingsFemaleHumansMaleMiddle AgedProspective StudiesQuality-Adjusted Life YearsTime FactorsTreatment Outcomebiventricular pacingcardiac resynchronization therapycost‐utilityheart failureleft bundle branch area pacing

Identifiers

PMID41319126
PMCPMC12891770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.