ArticleJournal of clinical laboratory analysis2025
Iron Profile Variability in Hemodialysis Chronic Kidney Disease Patients.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Inflammation and Erythropoietin Resistance in Chronic Kidney Disease: A Cross-Sectional Study of C-Reactive Protein and Anemia in Hemodialysis Patients.Journal of clinical laboratory analysis · 2026Article
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4 authors.
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Abstract
backgroundChronic kidney disease (CKD) constitutes one of the most important global health challenges and iron deficiency (ID) anemia is a frequent complication, especially in patients on dialysis.
objectivesThis study aimed to assess differences in iron profile in dialysis-adherent and non-adherent chronic kidney disease subjects and analyze the profiles between both groups.
methodsOne hundred and twenty patients undergoing hemodialysis were included in this cross-sectional study, classified into two subcategories of dialysis adherence. The parameters of iron profile-also defined as serum ferritin, transferrin saturation (TSAT), hemoglobin, and serum iron-were studied. Multivariate regression analysis was carried out, adjusting for possible confounders such as age, sex, diabetes, and duration of dialysis.
resultsSerum ferritin was significantly higher among adherent patients (235.6 ± 120.2 ng/mL vs. 185.2 ± 105.3 ng/mL; p = 0.03), as were TSAT (33.4% ± 9.3% vs. 28.8% ± 10.2%; p = 0.02) and hemoglobin (11.5 ± 1.8 g/dL vs. 10.2 ± 2.1 g/dL; p = 0.04). Non-adherence to the therapy was associated with a significantly higher number of patients having iron deficiency anemia (63% in non-adherent vs. 40% in adherent patients; p = 0.01). Multivariate analysis confirmed that dialysis adherence was independently associated with better iron status (p < 0.05 for all parameters).
conclusionIn hemodialysis patients, adherence to dialysis presents as a strong predictor of a better iron profile. Strategies that improve adherence to dialysis treatment by optimizing iron metabolism among chronic kidney disease patients should be in place.
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