SynthesisBrain and behavior2025
Risk Factors for Mortality in Stroke Patients Admitted to Critical Care Units: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Risk Factors for Mortality in Stroke Patients Admitted to Critical Care Units: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is a leading cause of morbidity and mortality worldwide, and patients admitted to intensive care units (ICUs) who require mechanical ventilation face an even higher risk of adverse outcomes, including increased mortality. Effective management in ICUs is crucial to improve patient outcomes.
aimThis systematic review and meta-analysis aimed to synthesize existing evidence on the risk factors associated with mortality in stroke patients admitted to any form of critical care units.
methodsA comprehensive search was conducted across four databases: PubMed, Web of Science, Scopus, and Embase, up to July 9, 2024. Studies were included if they evaluated mortality risk factors in adult stroke patients admitted to critical care units. Data were extracted and analyzed using a random-effects model to account for heterogeneity. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for various risk factors.
resultsEighteen studies involving 20,442 patients were included in the meta-analysis. Age was significantly associated with increased mortality (OR = 1.02; 95% CI: 1.01, 1.04). Lower Glasgow coma scale (GCS) scores were linked to higher mortality (OR = 0.93; 95% CI: 0.86, 1.01), though not statistically significant (P = 0.08). Higher National Institutes of Health Stroke Scale (NIHSS) scores showed a significant association with increased mortality (OR = 1.06; 95% CI: 1.03, 1.09), (p < 0.0001). Mechanical ventilation and higher body temperature (≥37.5°C) were associated with a higher risk of death (OR = 1.9; 95% CI: 1.65, 2.18) and (OR = 2.03; 95% CI: 1.56, 2.66) respectively. Atrial fibrillation (OR = 1.19; 95% CI: 1.06, 1.34) significantly contributed to mortality risk, while a higher body mass index (BMI) was not associated with a reduced risk of mortality (OR = 0.97; 95% CI: 0.92, 1.02).
conclusionThis study highlights the critical importance of early identification and targeted management of high-risk stroke patients in critical care settings. Age, neurological status, respiratory support needs, and specific comorbidities are key factors that clinicians should consider improving survival outcomes. Further research is needed to refine these findings and optimize care strategies for critically ill stroke patients.
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