Evidence map›Paper›PMID 41318981›Full record

ReviewThe clinical respiratory journal2025

Lineage Tracing of Distal Lung Epithelial Progenitors in Injury-Induced Regeneration.

Jian Xu, Yuhan Wang, Cuiping Zhang, Xiaoyan Chen, Tianchang Wei, Weiqi Mao, Yuanlin Song

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The clinical respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian XuDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0003-0280-3632
Yuhan WangShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Cuiping ZhangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoyan ChenDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Tianchang WeiDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Weiqi MaoDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuanlin SongDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-3373-6631

Funding

China Postdoctoral Science Foundation 2024 M750545National Key Research and Development Program of China 2024YFC3044400National Natural Science Foundation of China 82130001National Natural Science Foundation of China 82272243National Natural Science Foundation of China 82500110Outstanding Resident Clinical Postdoctoral Program of Zhongshan Hospital Affiliated to Fudan University 2025ZYYS-004R&D Program of Guangzhou National Laboratory GZNL2024A02003Science and Technology Commission of Shanghai Municipality 22Y11900800Shanghai Municipal Key Clinical Specialty shslczdzk02201Shanghai Municipal Science and Technology Major Project ZD2021CY001Shanghai Three-Year Action Plan to Strengthen the Construction of the Public Health System GWVI-11.1-18
6 · The paper itself

Abstract

backgroundLineage tracing is an emerging technology with the outstanding advantage of labeling stem cells and their descendants with temporal and spatial specificity in vivo. We aimed to systematically review the research advances of distal lung epithelial progenitors via lineage tracing strategies.

resultsThe distal lung, including bronchioles and alveoli, carries the respiratory function and is the central region involved in acute respiratory distress syndrome and other diseases. Many endogenous epithelial stem cell/progenitor lineages such as Club cells, alveolar type II cells, bronchioalveolar stem cells, and basal-like progenitors that contribute to distal lung regeneration have been identified and are engaged in repairing lung injury for various reasons. Advances in lineage tracing technology have provided tremendous support in characterizing progenitor lineages, identifying new progenitor cell lineages, and discovering regulators of their behaviors.

conclusionsThe important role of distal lung epithelial progenitors and lineage tracing methods has been highlighted in recent years. Relevant studies provide a perspective for further deepening lineage tracing in lung progenitor research and laying the groundwork for endogenous stem cell therapies in the future.

Indexed as

Cell LineageEpithelial CellsLungLung InjuryRegenerationStem CellsAnimalsHumansPulmonary Alveoliepithelial progenitorslineage tracinglung injuryregenerationstem cells

Identifiers

PMID41318981
PMCPMC12664906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.