Evidence map›Paper›PMID 41318948›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

A Click-Type Reaction of (RRR)-α-Tocopherol and Related 6-Chromanols Allowing a One Pot Derivatisation of All Fat-Soluble Vitamins.

Frederic Bourgeois, Simon Grünig, Waldemar Ens, Helen Yeman, Estel Canet, Belén Nieto-Ortega, Guido Wahl, Manuela Baur, Thomas Netscher, Ulrich Höller

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Frederic BourgeoisScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.ORCID https://orcid.org/0000-0003-4790-4341
Simon GrünigScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Waldemar EnsScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Helen YemanScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Estel CanetScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Belén Nieto-OrtegaScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Guido WahlScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Manuela BaurScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.
Thomas NetscherScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.ORCID https://orcid.org/0000-0002-9362-3244
Ulrich HöllerScience & Research, Analytical Sciences and Chemical Process Sciences, dsm-firmenich, Basel, Switzerland.ORCID https://orcid.org/0009-0004-8186-3429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(RRR)-α-tocopherol reacts with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) at ambient conditions in a fast formal [6+2+2] addition reaction yielding four pairs of diastereomers, three of them containing novel heterocyclic ring systems. Structure elucidation required customized 3,5-

Indexed as

alpha-TocopherolClick ChemistryVitaminsChromansCycloaddition ReactionEmulsionsFatty AcidsMolecular StructurePhospholipidsStereoisomerismVitamin AVitamin D2,2,5,7,8-pentamethyl-1-hydroxychromanalpha-TocopherolChromansEmulsionsfatty acid, fat-soluble vitamin and phospholipid emulsionFatty AcidsPhospholipidsVitamin AVitamin DVitamins4‐phenyl‐1,2,4‐triazoline‐3,5‐dioneaddition reactionheterocyclesvitamin analysisvitamin E adductsvitamins

Identifiers

PMID41318948
PMCPMC13451569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.