ArticleNeurology and therapy2026
Elevated Blood Alcohol Concentration at Stroke Onset Predicts Poor Clinical Outcomes and Mortality After Intracerebral Hemorrhage: A Retrospective Cohort Study.
Article in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Association of healthy lifestyle with incident cardiovascular diseases in individuals with type 1 diabetes mellitus: a prospective cohort study.Diabetology & metabolic syndrome · 2026Article
- Diabetes mellitus and efficacy of dual antiplatelet in acute ischemic stroke: A post hoc analysis of the ATAMIS trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Observational
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15 authors.
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Abstract
introductionThe impact of acute alcohol consumption at the onset of spontaneous non-traumatic intracerebral hemorrhage (ICH) remains unclear. We evaluated the association between elevated blood alcohol concentration (BAC) at admission and clinical outcomes in patients with ICH.
methodsThis retrospective single-center cohort study analyzed 1081 patients admitted with ICH between 2000 and 2023. BAC was measured at admission when alcohol use was suspected. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) and the Glasgow Coma Scale (GCS). Outcomes-7-day neurological deterioration (ND), mortality, 90-day modified Rankin Scale (mRS) scores-were analyzed using logistic and Cox regression models to assess associations with acute alcohol consumption.
resultsPatients that were BAC positive (alcohol group; n = 31, 2.9%) were younger, predominantly male, had larger hematoma volumes, showed significantly higher rates of 7-day ND (58.1% vs. 27.6%, p < 0.001) and mortality at 7, 30, and 90 days (51.6% vs. 23.7%, 71% vs. 37.6%, 71% vs. 43.3%, all p < 0.001) than patients with no clinical suspicion of alcohol consumption (control group; n = 1050, 97.1%). Multivariable Cox regression identified elevated BAC as an independent predictor of mortality at all time points (HR 2.089, 95% CI 1.091-3.997, p = 0.026 at 7 days; HR 2.133, 95% CI 1.220-3.728, p = 0.008 at 30 days; HR 2.096, 95% CI 1.214-3.622, p = 0.008 at 90 days). Multivariate logistic regression identified elevated BAC as an independent predictor of 7-day ND (OR 4.188, 95% CI 1.163-15.078, p = 0.028) and large ICH volume (≥ 30 cm
conclusionElevated BAC at ICH onset independently predicts early ND and increased mortality, indicating a potentially modifiable prognostic factor in acute ICH. These results underscore the importance of BAC measurement in patients with suspected alcohol consumption and warrant further research aimed at understanding and mitigating its potential detrimental effects.
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