ArticlePediatric research2026
Association of blood component transfusions with neurodevelopmental impairment in preterm infants by gestational age.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransfusion is frequently prescribed for preterm infants and known to be associated with adverse outcomes. We evaluated the association between transfusions of red blood cells (RBCs), platelets, and plasma in preterm infants and neurodevelopmental impairment (NDI).
methodsThis retrospective cohort study included 706 preterm infants. The primary outcome was severe NDI diagnosed at 18-30 months of corrected age. After adjusting, weighted logistic regression was performed to evaluate the associations between each transfusion type, the number of transfusions, and severe NDI.
resultsRBC transfusions were associated with severe NDI in both subgroups (<32 weeks: adjusted odds ratio [aOR] 2.47; 95% confidence interval [CI] 1.13-5.44; ≥32 weeks: aOR 8.13; 95% CI 3.39-19.52). Platelet transfusions were associated with severe NDI in the <32-week group (aOR 2.53; 95% CI 1.26-5.08) but not in the ≥32-week group (aOR 1.20; 95% CI 0.10-14.17). Plasma transfusions were associated with severe NDI in the ≥32-week group (aOR 2.69; 95% CI 1.38-5.24) but not in the <32-week group (aOR 1.19; 95% CI 0.58-2.42).
conclusionsTransfusions may be associated with severe NDI risk in preterm infants, and this association may differ according to the type of blood product and gestational age at birth. IMPACT: In addition to RBC and platelet, plasma transfusions are also linked to a higher risk of NDI by two years of corrected age. The association between transfusions and NDI varies by type of blood product and gestational age, with RBC and plasma transfusions posing a greater risk closer to term. Transfusions should be minimized by considering the differing risks based on blood product and gestational age, and further studies are warranted to explore the newly identified association between plasma transfusions and NDI.
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