Evidence map›Paper›PMID 41318758›Full record

ArticleScientific reports2025

Sex differences in cardiac graft recovery and pathophysiologic changes in a rat model of donation after circulatory death.

Alexia Clavier, Selianne Graf, Anja Helmer, Deborah Lagger, Manuel Egle, Adrian Segiser, Matthias Siepe, Maria Arnold, Sarah Longnus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexia Clavier *Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Selianne Graf *Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Anja HelmerDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Deborah LaggerDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Manuel EgleDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Adrian SegiserDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Matthias SiepeDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Maria ArnoldDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Sarah LongnusDepartment of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland. sarah.henninglongnus@insel.ch.

Funding

Swiss National Science Foundation 310030_205073Swiss National Science Foundation 323530_207033
6 · The paper itself

Abstract

Biological sex affects cardiac tolerance to ischemia and reperfusion, but little is known about sex differences in heart transplantation with donation after circulatory death (DCD). Using a rat model, we characterized differences between sexes both in the donor, during simulated DCD, and in the procured heart, to evaluate recovery upon reperfusion. Adult male, female and ovariectomized Wistar rats underwent simulated DCD with 22 min of warm, in-situ ischemia. Hearts were then explanted and maintained in cold static storage for 30 min. Isolated hearts then underwent normothermic, oxygenated reperfusion for 60 min with left ventricular loading. In-situ characteristics, as well as ventricular function, coronary flows and metabolic post-ischemic recovery were assessed. Post-ischemic ventricular recovery was significantly higher in female compared to male and ovariectomized hearts. Furthermore, several in-situ circulating factors, including free fatty acids and potassium, were significantly lower in females compared with males. Greater post-ischemic ventricular function in female vs. male and ovariectomized hearts following DCD indicates that sex affects tolerance to DCD conditions and that female sex hormones contribute to cardioprotection. Greater understanding of sex-specific tolerance to DCD conditions may serve as a basis to better define precise mechanisms of cardiac injury and thereby contribute to optimizing clinical protocols.

Indexed as

Heart TransplantationSex CharacteristicsAnimalsDisease Models, AnimalFemaleHeartMaleMyocardial Reperfusion InjuryOvariectomyRatsRats, WistarSex FactorsCardiac ischemia/reperfusion injuryDonation after circulatory death (DCD)Ex-situ/ex-vivo heart perfusionHeart transplantationSex as a biological variable (SABV)

Identifiers

PMID41318758
PMCPMC12756239

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.