Evidence map›Paper›PMID 41318731›Full record

ArticleScientific reports2025

Cytotoxicity and cell cycle changes in prostate cancer cells with differing PSMA expression and p53 status after treatment with PSMA-targeting radioligand [

Vilde Yuli Stenberg, Rugile Liukaityte, Sandra Kvarsvik Kristiansen, Rina Wangen-Riise, Andrius Kleinauskas, Victoria Dunne, Asta Juzeniene

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vilde Yuli Stenberg *Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Rugile Liukaityte *Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Sandra Kvarsvik KristiansenDepartment of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Rina Wangen-RiiseDepartment of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Andrius KleinauskasDepartment of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Victoria DunneJohnston Cancer Research Centre, Queen's University Belfast, Belfast, BT9 7AE, UK.
Asta JuzenieneDepartment of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. astaj@ous-hf.no.

Funding

European Union's Horizon 2020 research and innovation programme No 101008571 (PRISMAP)Prostate Cancer UK Career Acceleration Fellowship TLD-PF21-001Radiumhospitalets Forskningsstifltelse TARACAN
6 · The paper itself

Abstract

Targeted alpha therapy holds promise for treating advanced prostate cancer, but the interplay between prostate-specific membrane antigen (PSMA) expression, p53 status, and downstream cell fate remains poorly defined. This study evaluates the cytotoxic and cell cycle effects of the alpha-emitting radioligand [

Indexed as

Antigens, SurfaceCell CycleGlutamate Carboxypeptidase IILead RadioisotopesProstatic NeoplasmsRadiopharmaceuticalsTumor Suppressor Protein p53Cell Line, TumorCell ProliferationCell SurvivalHumansMalePC-3 CellsAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILead RadioisotopesRadiopharmaceuticalsTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID41318731
PMCPMC12775525

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.