Evidence map›Paper›PMID 41318714›Full record

ArticleMycopathologia2025

Retrospective Multicenter Study on Invasive Candidiasis in Türkiye Demonstrates High Genetic Variety of Candida tropicalis.

Bram Spruijtenburg, Nevzat Ünal, Asuman Birinci, Muhammed Alper Özarslan, Ramazan Gümral, Theun de Groot, Jacques F Meis, Ayşe Sultan Karakoyun, Macit Ilkit, Eelco F J Meijer

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bram SpruijtenburgDepartment of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands. Bram.spruijtenburg@radboudumc.nl.ORCID http://orcid.org/0000-0002-6734-361X
Nevzat ÜnalDivision of Mycology, Department of Microbiology, Faculty of Medicine, Çukurova University, Adana, Türkiye.
Asuman BirinciDepartment of Microbiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Türkiye.
Muhammed Alper ÖzarslanDivision of Mycology, Department of Microbiology, Faculty of Medicine, Ege University, Izmir, Türkiye.
Ramazan GümralDivision of Mycology, Department of Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Türkiye.
Theun de GrootRadboudumc-CWZ Center of Expertise for Mycology, Nijmegen, The Netherlands.
Jacques F MeisRadboudumc-CWZ Center of Expertise for Mycology, Nijmegen, The Netherlands.
Ayşe Sultan KarakoyunDivision of Mycology, Department of Microbiology, Faculty of Medicine, Çukurova University, Adana, Türkiye.
Macit Ilkit *Division of Mycology, Department of Microbiology, Faculty of Medicine, Çukurova University, Adana, Türkiye.
Eelco F J Meijer *Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands.

Funding

Canisius-Wilhelmina Hospital CWZ_001421Çukurova Üniversitesi TDK-2021-14216
6 · The paper itself

Abstract

Candida tropicalis frequently causes invasive infections in immunocompromised hosts. Mortality rates are high compared to other yeasts, while antifungal resistance varies between countries. To date, multicenter studies regarding C. tropicalis infections in Türkiye are limited. The current study therefore characterized C. tropicalis infections in Türkiye. In this retrospective study, 120 invasive C. tropicalis isolates were collected from four hospitals in Türkiye, mostly from blood. In vitro antifungal susceptibility testing (AFST) was performed for eight common antifungals, and short tandem repeat (STR) genotyping was applied to investigate genetic relatedness within the current population and previously genotyped isolates. Patients with invasive C. tropicalis candidiasis were mostly elderly, with a central venous line (CVL) and cancer or diabetes as underlying disease, and an overall mortality rate of 37%. Except for a single isolate from blood being resistant to fluconazole and voriconazole, no resistance to common antifungals was found. Finally, nosocomial transmission within hospitals was limited as nearly all isolates displayed unique genotypes. When compared to 605 previously investigated isolates from 12 diverse countries, only few clusters were present, indicating an overall high genetic diversity for C. tropicalis. While isolates from the current study did not form a single monophyletic branch, there were 27 isolates that formed a distinct pan-susceptible clade together with isolates of other Middle Eastern countries. To conclude, we described a retrospective multicenter study on invasive C. tropicalis infections in Türkiye characterized by a high mortality rate for untreated patients, while isolates showed little antifungal resistance and high genetic diversity.

Indexed as

Candida tropicalisCandidiasis, InvasiveGenetic VariationAdolescentAdultAgedAged, 80 and overAntifungal AgentsChildChild, PreschoolCross InfectionFemaleGenotypeHospitalsHumansInfantAntifungal AgentsAntifungal resistanceCandida tropicalisCandidemiaGenotypingInvasive candidiasisShort tandem repeats

Identifiers

PMID41318714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.