ArticleNature communications2025
Anatomy-to-tract mapping infers white matter pathways without diffusion streamline propagation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- A subject-specific reversible folding model reveals geometry-driven white-matter organization.bioRxiv : the preprint server for biology · 2025Article
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6 authors.
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Abstract
Diffusion tractography, a cornerstone of white matter mapping, relies on point-to-point streamline propagation, a process often limited by the signal-to-noise ratio and spatioangular resolution of diffusion MRI (dMRI). Here, we present Anatomy-to-Tract Mapping (ATM), a framework that generates bundle-specific streamlines directly from T1-weighted MRI without requiring orientation field estimation, voxelwise segmentation, or streamline propagation. ATM leverages the high quality and minimal distortion of anatomical MRI and learns from paired T1w and tractogram data to synthesize anatomically plausible, subject-specific streamlines. This anatomy-driven approach addresses complex configurations such as crossing, kissing, and bending fibers, providing robust bundle reconstructions. Using the TractoInferno dataset with 30 white matter bundles, we evaluate ATM against diffusion-based methods, including MRtrix probabilistic tracking with BundleSeg and SCIL atlas warping. ATM demonstrates strong performance across multiple metrics, including bundle similarity, volume coverage, angular correlation, and geometric fidelity.
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