ArticleNature communications2025
High-throughput two-photon volumetric brain imaging in freely moving mice.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Review
- High-speed neural imaging with multiplexed miniaturized two-photon microscopy.Cell reports methods · 2025Article
- High-throughput two-photon volumetric brain imaging in freely moving mice.Nature communications · 2025Article
- Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Imaging neural activities across large volumes at subcellular resolution without impeding animal behaviors remains difficult. Here, we develop a high-throughput miniature Bessel-beam two-photon microscope (miniBB2p) capable of imaging calcium dynamics from neurons and dendrites over a volume of 420 × 420 × 80 μm³ during free behavior. We share a full description of miniBB2p and demonstrate its ability to perform large-scale recordings of the calcium activities of more than 1000 neurons at a time in anterior cingulate cortex and secondary motor cortex of freely moving mice in various behavioral paradigms. Our results position miniBB2p to advance the design of miniature multiphoton microscopes, facilitating precise monitoring of neural activities across large populations within a three-dimensional volume in freely moving animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.