Evidence map›Paper›PMID 41318669›Full record

ArticleActa neuropathologica communications2025

SPION

Xavier Alvarez, Zoey K Wallis, Cecily C Midkiff, Jaclyn Mallard, Pete J Didier, Kenneth C Williams

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xavier AlvarezImaging PET-CT and OIL Core, Southwest National Primate Research Center, San Antonio, TX, USA.
Zoey K WallisMorrissey College of Arts and Sciences, Biology Department, Boston College, 140 Commonwealth Ave, Chestnut Hill, MA, 02467, USA.
Cecily C MidkiffTulane National Biomedical Research Center, Covington, LA, USA.
Jaclyn MallardMorrissey College of Arts and Sciences, Biology Department, Boston College, 140 Commonwealth Ave, Chestnut Hill, MA, 02467, USA.
Pete J DidierTulane National Biomedical Research Center, Covington, LA, USA.
Kenneth C WilliamsMorrissey College of Arts and Sciences, Biology Department, Boston College, 140 Commonwealth Ave, Chestnut Hill, MA, 02467, USA. kenneth.williams.3@bc.edu.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
MONOCYTE TRAFFIC AND THE NEUROPATHOGENESIS OF AIDSR01NS040237 · NINDS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Robert Blair, Woong-Ki Kim · 1999 to 2026
$11.4M
Effects of CSF1R Blockade on Repopulation of SIV Reservoirs from the CNS to the Periphery After Antiretroviral Therapy InterruptionR01NS126091 · NINDS · BOSTON COLLEGE · PI KIM, WOONG-KI, WILLIAMS, KENNETH C · 2021 to 2025
$3.6M
NIH HHS P51 OD011104NIH HHS P51 OD011133NIHNINDS NIH RO1 NS040237, and RO1NS126091NINDS NIH HHS R01 NS040237NINDS NIH HHS R01 NS126091
6 · The paper itself

Abstract

Central nervous system (CNS) macrophages play key roles in viral neuropathogenesis and immune surveillance, yet their trafficking and trafficking dynamics between the CNS and peripheral lymphoid tissues remain poorly understood. To address this gap, we used intracisternal (i.c.) injection of fluorescent-superparamagnetic iron oxide nanoparticles (SPION) in SIV-infected macaques that we found labeled CNS CD68

Indexed as

Cell MovementCentral Nervous SystemMacrophagesMagnetite NanoparticlesSimian Acquired Immunodeficiency SyndromeAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenMacaca mulattaMaleReceptors, Cell SurfaceSimian Immunodeficiency VirusAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenMagnetite NanoparticlesReceptors, Cell SurfaceCell-trafficHIVMacrophageMonocytesSIV

Identifiers

PMID41318669
PMCPMC12771750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.