Evidence map›Paper›PMID 41318662›Full record

Trial reportScientific reports2025

The impact of PEEP-guided electrical impedance tomography on oxygenation and respiratory mechanics in moderate-to-severe ARDS: a randomized controlled trial.

Dinh Van Trung, Bui Thi Huong Giang, Dang Quoc Tuan, Nguyen Cong Tan, Pham The Thach, Bui Van Cuong, Nguyen Ba Cuong, Trinh The Anh, Nguyen Tu Anh, Nguyen Van Huy and 19 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06733168 (The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06733168 narecruitingnot on this map

The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS

TypeinterventionalSponsorVietnam Military Medical UniversityRan2024 to 2026Enrolled76ConditionsAcute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Mechanical Ventilation, Electrical Impedance Tomography (EIT)Armselectrical impedance tomography, Non-EIT
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Dinh Van TrungDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Bui Thi Huong GiangDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Dang Quoc TuanDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Nguyen Cong TanDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Pham The ThachDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Bui Van CuongDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Nguyen Ba CuongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Trinh The AnhCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Tu AnhDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Nguyen Van HuyDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam.
Ho Duc TrieuCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Van TrongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Tran Thu TrangCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Vuong Xuan ToanCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Hoang NamCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Thi SamCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Truong Mau ThanhCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Tien DatCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nghiem Thi Phuong HongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Pham Thi Hong PhuongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Dang Duy HienCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Do Van HoiCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Hoang Tuan PhongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Nguyen Dang ThuDepartment of Anesthesiology, Military Hospital 103, Vietnam Military Medical University, No.261 Phung Hung Street, Ha Dong Ward, Hanoi, 12108, Vietnam.
Nguyen Thao TrangCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Ngo Xuan HieuCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Hoang Tien DatCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Dao Xuan PhuongCenter for Critical Care Medicine, Bach Mai Hospital, No. 78 Giai Phong Street, Kim Lien Ward, Hanoi, Vietnam.
Do Ngoc SonDepartment of Emergency and Critical Care Medicine, Hanoi Medical University, No. 01, Ton That Tung Street, Kim Lien Ward, Hanoi, 11520, Vietnam. sonngocdo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP with low PEEP/FiO₂ strategy in patients with moderate-to-severe ARDS. In this randomized controlled trial, 108 patients with PaO₂/FiO₂ below 200 mmHg were allocated to EIT-guided PEEP after a recruitment maneuver (n = 56) or low PEEP/FiO₂ strategy (n = 52). Patients in the EIT group underwent PEEP titration guided by the intersection point between alveolar overdistension and collapse during a decremental PEEP trial. Primary outcomes were oxygenation (PaO₂/FiO₂) and static compliance. Secondary outcomes included mortality, ventilator-free days, ICU stay, barotrauma, rescue therapies, and sequential organ failure assessment (SOFA) score changes. On day 1, oxygenation was higher with EIT (mean PaO₂/FiO₂ 180 vs. 159 mmHg; p = 0.036). Static compliance was greater at both day 1 (26 vs. 23 mL/cmH₂O; p = 0.016) and day 2 (27 vs. 24 mL/cmH₂O; p = 0.029). Driving pressure was lower with EIT at day 1 (16 vs. 17 cmH₂O; p < 0.001) and day 2 (15 vs. 17 cmH₂O; p = 0.005). SOFA scores improved more in the EIT group (day 1: - 1 vs. 0, p = 0.013; day 2: - 1 vs. - 0.5, p = 0.015). Twenty-eight-day mortality was lower with EIT (29 vs. 44%), although not statistically significant (p = 0.090). ICU stay, ventilation duration, barotrauma, ECMO use, and rescue therapies were similar. Benefits were most pronounced in patients with severe ARDS. EIT-guided PEEP improved oxygenation, lung mechanics, and reduced organ dysfunction in moderate-to-severe ARDS, particularly in severe cases. It showed a trend toward reduced mortality and may serve as a practical bedside tool for lung-protective ventilation. Larger multicenter trials are needed to confirm its clinical benefits.Trial registration: ClinicalTrials, NCT06733168. Registered on 13/12/2024, https://clinicaltrials.gov/study/NCT06733168 .

Indexed as

OxygenPositive-Pressure RespirationRespiratory Distress SyndromeRespiratory MechanicsTomographyAdultAgedElectric ImpedanceFemaleHumansMaleMiddle AgedTreatment OutcomeVentilator-Induced Lung InjuryOxygenARDSElectrical impedance tomographyOxygenationPEEPRespiratory mechanics

Identifiers

PMID41318662
PMCPMC12770395

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.