ArticleEuropean journal of medical research2025
The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glycolytic Reprogramming Mediated by the OTUD4-FXR1-HIF1A Axis Drives Gastric Cancer Progression.International journal of biological sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is essential for regulating immune responses in tumours. The molecular processes regulating its activation in pancreatic cancer remain elusive. We demonstrate that ribosomal protein L6 (RPL6) directly interacts with cGAS, hence initiating cGAS-STING signalling in malignant pancreatic cells. Data mining from open-access sources demonstrated a strong positive connection between RPL6 abundance and immune cell infiltration. The forced expression of RPL6 greatly boosted the production of interferon-β in pancreatic cancer cells. In addition, diaphanous-related formin 3 (DIAPH3) reduced RPL6 protein levels by disrupting its interaction with the deubiquitinase OTUD4. Our results demonstrate that RPL6-mediated stimulation of cGAS-STING signalling profoundly influences immune control in pancreatic cancer, highlighting this pathway as a potential therapeutic target.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.