ArticleNPJ Parkinson's disease2025
Mapping the neural and molecular basis underlying fatigue in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Functional gradient variations in different neuroticism levels and its correlation with cell type-specific transcriptional signatures.Social cognitive and affective neuroscience · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
Fatigue is a common and debilitating non-motor symptom in patients with Parkinson's disease (PD). By integrating the activation likelihood estimation (ALE) meta-analysis and activation network mapping (ANM) technique, the brain network underlying fatigue (referred to as "fatigue-related network") in PD was identified, comprising widespread brain regions primarily involving the somatomotor and frontoparietal networks. This network was interpreted through transcriptomic patterns, chemoarchitectures, and behavioral relevance. Fatigue-related genes were predominantly enriched in synaptic and actin filament-related biological processes and showed primary expression in neurons and oligodendrocytes. The fatigue-related network closely corresponded to the spatial distribution of acetylcholine, glutamate, and norepinephrine systems and was primarily linked to motor function. This study defines a distinct brain network substrate underlying fatigue in PD, advancing our understanding of the neurobiological mechanisms and facilitating the development of effective therapies for affected patients.
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